Validated Gc Method for Determination of Validol in Tablet Dosage Forms
نویسندگان
چکیده
A validated method for the determination of validol in tablet dosage forms using gas chromatography with flame-ionization detection and n-octanol as the internal standard is developed. Validol represents a 25-30% solution of menthol in the menthyl ester of isovaleric acid. The separation of both compounds was achieved on a HP-FFAP (nitroterephthalic acid modified polyethylene glycol) fused silica capillary column, 30 m x 0.53 mm i.d. with 1 μm stationary film thickness. The linearity was established in the range from 0.448 to 2.240 mg/ml for menthol and from 1.152 to 5.762 mg/ml for menthyl isovalerate, respectively. Validation results showed that the method is selective, linear, accurate and precise.
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تاریخ انتشار 2012